Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system.

HE staining revealed that, on day 3, the number of morphologically healthy follicles was significantly greater in the Ctrl and MSC groups than in the Cryo group, whereas the increase in the EV group did not reach statistical significance.

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The Ctrl and MSC groups maintained significantly greater proportions than the Cryo group did, while the EV group showed an increasing trend without statistical significance ( Fig. 7 B and C).

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