Preliminary evidence for the integration of CNAs, CN-LOH and mutational profiles into the prognostic stratification of elderly patients with <i>NPM1</i>-mutated acute myeloid leukemia.

Although this association did not reach statistical significance in the multivariate analysis, these observations tentatively suggest a mechanistic basis for the pronounced prognostic heterogeneity within this vulnerable subgroup and highlight the need to refine risk stratification beyond conventional AML classification systems.

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