An Exploratory Randomized Controlled Trial of 0.9% Saline Versus Lactated Ringer's Solution on Intraoperative Metabolism Among Patients Undergoing Lumbar Spinal Surgery.

Patients receiving lactated Ringer's solution also had a strong trend of lower concentrations of plasma hydroxyisocaproic acid (interaction P = .055), a leucine degradation metabolite, and smaller decreases in phospholipid breakdown anti-inflammatory metabolite concentrations, namely 15-ketoeicosatetraenoic acid (15-oxoETE, interaction P = .063).

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A group by time interaction effect with P < .10 indicated a statistical trend strongly toward significance 22 and this interaction effect reflects differential perioperative trajectories between crystalloid groups, rather than isolated postoperative differences.

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