MYC-Mediated Functional Manifestation of IDH1 Mutations in Intrahepatic Cholangiocarcinoma Confers Sensitivity to (+)-JQ1.

Int J Biol Sci · 2026 · PMC12965060 · PMID 41800252

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did not reach statistical significanceno p-value reported

However, results from the ClarIDHy phase III clinical trial 17 revealed that though ivosidenib-treated ICC patients showed prolonged median overall survival compared to placebo controls, this improvement did not reach statistical significance.

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