PD-1 inhibitor-induced rheumatic, endocrine, and sarcoidosis-like immune-related adverse events in metastatic melanoma are associated with improved survival and lower corticosteroid exposure.

Immunother Adv · 2026 · PMC12965203 · PMID 41800115

Europe PMC DOI

hedged sentences

0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

showed a trendP = 0.067so close (0.05 < p ≤ 0.1)

Patients treated with a high initial corticosteroid dose (>0.5 mg/kg) also showed a trend toward improved survival (HR: 0.63, 95% CI: 0.38–1.04, P = 0.067; Fig. 6b ).

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borderline significantno p-value reported

Of the eight most common irAEs, four were associated with superior survival, one was borderline significant, and three were non-significant.

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