Application of Indocyanine Green in the Detection of Sentinel Lymph Nodes in Laparoscopic Staging Surgery for Endometrial Cancer: A Retrospective Cohort Study.

2 mL) did not significantly improve the mapping rate.[ 28 ] The SENTIFAIL study analyzed 376 patients and demonstrated that failure of SLN mapping was related to lymphovascular space involvement, nonendometrioid histology, and intraoperative findings of enlarged lymph nodes.[ 30 ] The ObeLyx study in 2022 concluded that BMI is a statistically significant predictor of mapping failure and a decrease in the overall detection rate.[ 31 ] Our study demonstrated an increasing trend of failed SLN mapping with increased BMI, consistent with previous studies, despite conflicting data in other studies.[ 32 ] Obesity is known to negatively impact SLN mapping due to technical challenges, such as difficulty in accessing pelvic lymphatic pathways, reduced fluorescence penetration of

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Other studies have found that nonendometrioid histology, enlarged lymph nodes, and lymphovascular invasion increased failed SLN mapping rates.[ 25 , 36 , 37 ] However, our data did not reach statistical significance, possibly due to the small sample size; hence, further large-scale studies are required to clarify these associations.

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