Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and mouse models.

Comparatively, although not statistically significant, control neurons treated with EVs derived from SHANK3 mutant neurons showed a trend toward increased Na+ currents after EV swapping (p = 0.49) (Fig. 2d, f ).

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Additionally, the rate of spontaneous APs (see methods) showed a decreasing trend but a non-significant change (p = 0.29) after MSC-EVs treatment (Fig. 4m–o for representative images and averages).

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