Evolving Characteristics of Rheumatoid Arthritis Patients Receiving Primary Hip or Knee Arthroplasty: A 21-Year Single-Center Trend Analysis (2002-2022).

Orthop Surg · 2026 · PMC12967458 · PMID 41592741

Europe PMC DOI

hedged sentences

0.2200

closest p · 4.4× alpha

0.2200

boldest claim

The sentences

a significant trendp = 0.220not close (p > 0.1)

NSAIDs use did not show a significant trend ( p = 0.220). 3.3.

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a decreasing trendno p-value reported

Although there was a significantly increasing trend for the preoperative use of csDMARDs and bDMARDs + tsDMARDs, and a decreasing trend for inflammatory markers from trend analysis and intergroup comparisons (2002–2011 vs. 2012–2022), the overall percentage of preoperative use of csDMARDs and bDMARDs + tsDMARDs in our cohort was as low as 36.3% and 6.2%, respectively.

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an increasing trendno p-value reported

The use of glucocorticoids (GCs) before surgery demonstrated a significant decreasing trend while conventional synthetic disease‐modifying anti‐rheumatic drugs (csDMARDs) and biological DMARDs (bDMARDs) + targeted synthetic DMARDs (tsDMARDs) demonstrated an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.