Six-month randomized, double-blind trial of transcranial direct current stimulation in mild Alzheimer's dementia: domain-specific cognitive and neuropsychiatric signals.

In the ITT population, the active group was relatively stable or showed a slight improvement (37.45 ± 11.31 to 37.96 ± 10.78; mean Δ +0.51), whereas the sham group exhibited a decline (35.23 ± 13.15 to 32.91 ± 14.00; mean Δ −2.32), yielding a nominally significant between-group difference in change ( p = 0.022; Table 2 ).

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In our larger mild dementia cohort, we did not detect a benefit of tDCS on K-MMSE–defined global cognition, but we did observe a small, statistically significant advantage in confrontation naming (K-BNT) favoring active tDCS and a numerical trend toward greater change on the RCFT in the active arm.

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