Barely Significant
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UVB Upregulates Inflammatory Cytokines in Rosacea Cell Model by Promoting the Expression of TRPVs and TLR2.

Immunotargets Ther · 2026 · PMC12968807 · PMID 41809119

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And the mRNA expressions of TRPV2 and TRPV3 exhibited an increasing tendency, variations did not reach statistical significance.

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a decreasing trendno p-value reported
There was a decreasing trend in the secretion levels of IL-1β and IL-8, but the difference was not statistically significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.