Similarity of sputum mediator signatures between e-cigarette users and COPD depends on GOLD stage and type of e-cigarette: a pilot study.

Although distances between e-cigarette user groups and COPD groups did not reach statistical significance, we noted a trend towards similarity. 4 th gen e-cig users were close in multivariate space to pre-COPD participants for the all mediator dataset (15 th percentile) and the protease and enzyme dataset (11 th percentile), and 3 rd gen e-cig users were close in multivariate space to GOLD stage 3 participants in the chemotactic mediators dataset (11 th percentile).

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