Cerebral oxygen extraction and blood flow in community-based older adults: associations with white matter hyperintensity and neurocognitive function.

In APOE4 non-carriers, OEF was negatively associated with attention ( β = −0.04, 95% CI = [−0.07, −0.00]) and visuospatial function ( β = −0.05, 95% CI = [−0.08, −0.01]) but not with memory; however, in APOE4 carriers, OEF and visuospatial function showed a positive association trend ( β = 0.10, 95% CI = [−0.01, 0.21]) that did not reach statistical significance ( Supplementary Fig. 5 ).

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