Hyaluronan induces ERK activation with minimal transcriptomic changes in pancreatic α-cells.

In HA-stimulated cells, several pathways potentially related to ERK signaling, including the calcium signaling pathway and glycerol phospholipid metabolism, showed a trend toward enrichment (nominal P -values <0.05), although they did not pass the predefined FDR threshold ( q -value <0.25) ( Supplementary Table S4 ).

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