Cross-tissue integrative transcriptomic and multimodal analyses suggest shared immune signatures linking lupus nephritis and cutaneous lupus erythematosus.

Moreover, both T-cell and B-cell compartments displayed an upward trend in the CLE group, although these changes did not reach statistical significance ( Figure 4D ).

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Quantitative assessment showed a decreasing trend in CD4 + T-cell proportions and a concomitant increasing trend in CD8 + T cells in CLE, although there were no statistical significance, resulting in an overall reduction of the CD4/CD8 ratio in the CLE patients group ( Figures 5B, C ).

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