STING predicts patterns of failure in locally advanced head and neck squamous cell carcinoma.

JNCI Cancer Spectr · 2026 · PMC12972654 · PMID 41569294

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.1200

boldest claim

The sentences

of borderline significanceP = .051so close (0.05 < p ≤ 0.1)

In multivariate analysis, p16 was a significant predictor for local control, whereas elevated STING was of borderline significance ( P = .051).

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borderline significantP = .054so close (0.05 < p ≤ 0.1)

However, in contrast to DFS, the prognostic power of STING expression in the stroma for LRF was eroded with a borderline significant association with LRC ( P = .054).

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a borderline significant trendP = .067so close (0.05 < p ≤ 0.1)

Conversely, high STING in the stromal compartment showed a borderline significant trend toward reduced DF ( P = .067; Figure 5A ).

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a nonsignificant trendP = .12not close (p > 0.1)

High levels of STING in tumor cells were of borderline significance ( P = .066), and analysis of total STING had a nonsignificant trend for improved DFS ( P = .12).

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