Ultrasonic repression of TRPA1-dependent astrocyte reactivity confers neuroprotection in models of Lewy body dementia.

Transl Neurodegener · 2026 · PMC12973804 · PMID 41808144

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The expression of Il-1r1 and Tlr2 , which showed a trend of increase in α-syn PFF-treated astrocytes, was suppressed by ultrasound application to be lower than the PBS-treated control level, even in the presence of α-syn PFFs (Fig. 2 d, e).

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