Genes whose differential expression failed to reach statistical significance (FDR < 0.05, log2FC > 1, < −1) between young and older muscle tissue and/or young and older differentiated muscle cell lines (represented in yellow in Supplementary Fig. 6 A) were then subtracted from the plot (Fig. 6 A).
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The transcriptomic signature of age and sex is not conserved in human primary myotubes.
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