Targeted BDNF upregulation via upstream open reading frame disruption.

Mol Ther · 2026 · PMC12974206 · PMID 41383011

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did not reach statistical significanceno p-value reported

Disruption of uORF-1 (weak Kozak context) resulted in an ∼1.3-fold increase in reporter expression that did not reach statistical significance, suggesting that its contribution to this repressive effect is minimal.

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