Transcriptomic profiling of clear cell renal cell carcinoma reveals age-dependent molecular signatures and clinical stratification patterns.

PLoS One · 2026 · PMC12974835 · PMID 41805734

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.1160

boldest claim

The sentences

marginally non-significantp = 0.051so close (0.05 < p ≤ 0.1)

Fig 2C presents PC2 score distributions showing a marginally non-significant trend (p = 0.051) toward higher PC2 values in young subjects.

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did not reach statistical significancep = 0.116not close (p > 0.1)

CK7 status was identified as a significant main effect ( p = 0.004), whereas the class × CK7 interaction did not reach statistical significance ( p = 0.116) ( S2 Fig B ), likely reflecting limited statistical power given the sample size.

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highly significantno p-value reported

Vertical dashed lines marked fold change thresholds (±1 log2) and horizontal lines indicated significance cutoffs, with highly significant genes (|log2FC| > 2 and padj < 1e-13) specifically labeled by gene symbol.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.