Methionine restriction provides sex-specific protection against high-fat diet-induced adiposity, peripheral insulin resistance, and neuroinflammation in FGF21-dependent and independent manners in mice.

PLoS One · 2026 · PMC12974880 · PMID 41805916

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did not reach statistical significanceno p-value reported

The HFD impaired insulin response in WT females, and MR did not improve this response but again appeared to elevate basal Akt phosphorylation, though this did not reach statistical significance ( Fig 7B ).

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