<i>EPB41L4A-AS1</i> long noncoding RNA acts in both <i>cis</i>- and <i>trans</i>-acting transcriptional regulation and controls nucleolar biology.

In agreement with studies on EPB41L4A function ( Ishiguro et al., 2000 ; Comiskey et al., 2020 ), these genes were enriched with those functioning in cell-cell adhesion and cell surface receptor signaling, although with a borderline significance ( Figure 2—figure supplement 2F ).

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While STARD4 – which was chosen because it had spatial contacts above background with EPB41L4A-AS1 – did not reach statistical significance, others did and are highlighted.

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