Barely Significant
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<sup>18</sup>F-FDG PET radiomic analysis to predict outcomes in metastatic melanoma treated with immune checkpoint inhibitors.

Front Immunol · 2026 · PMC12975435 · PMID 41822493

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a trend toward significanceno p-value reported
However, there was a trend toward significance for brain metastases in relation to PFS, which aligns with findings in the literature.

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highly significantno p-value reported
In conclusion, despite the inherent limitations commonly encountered in predictive modeling ( 51 ), our results were highly significant and demonstrated the promising predictive potential of FDG-PET/CT radiomics in metastatic CM patients treated with immunotherapy.

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showed a trendno p-value reported
Regarding OS, no significant factors were identified, although elevated baseline LDH levels showed a trend toward significance, consistent with previously published data ( 39 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.