However, there was a trend toward significance for brain metastases in relation to PFS, which aligns with findings in the literature.
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<sup>18</sup>F-FDG PET radiomic analysis to predict outcomes in metastatic melanoma treated with immune checkpoint inhibitors.
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In conclusion, despite the inherent limitations commonly encountered in predictive modeling ( 51 ), our results were highly significant and demonstrated the promising predictive potential of FDG-PET/CT radiomics in metastatic CM patients treated with immunotherapy.
Regarding OS, no significant factors were identified, although elevated baseline LDH levels showed a trend toward significance, consistent with previously published data ( 39 ).