GREB1-rearranged uterine tumour shares a common DNA methylation signature with ESR1-rearranged UTROSCT.

However, GREB1 ‐rearranged uterine tumours showed a trend for greater genomic instability, with a mean GI of 19.4 (median 19, range 2–40), compared to ESR1 ‐rearranged UTROSCT ( P = 0.07), which had a mean GI of 10.7 (median 8, range 2–20), and UTROSCT that had not undergone fusion testing ( P = 0.002), which had a mean GI of 6.31 (median 4, range 1–12) (Figure 4B ).

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