Clinical outcomes-dependent IgG epitope profiling in HTLV-1 reveals differential recognition of pathogen-derived antigens.

As shown in Figure 1 , all HTLV-1–infected individuals (ACs, HAM/TSP, and ATLL) exhibited strong reactivity to 44 epitopes, whereas healthy controls (HCs) displayed only low-intensity binding restricted to 9 epitopes, resulting in a highly significant difference (p < 0.001) for all HTLV-1–infected groups compared with HCs.

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Although other bacterial panels did not reach statistical significance, the overall response profiles clearly indicate systematic divergence in the breadth and magnitude of IgG recognition across groups.

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