The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Alzheimer's and Parkinson's disease: a systematic review and meta-analysis.

Front Aging Neurosci · 2026 · PMC12975910 · PMID 41822299

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showed a trendno p-value reported

Similarly, α-synuclein accumulation showed a trend toward reduced pathology in PLX-treated animals, with shorter treatment durations (3–5 weeks) showing the higher effect.

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a slight trendno p-value reported

The meta-analysis showed no neuroprotection with PLX treatment, despite a slight trend toward increased dopaminergic neurons and benefits in longer treatments (8–11 weeks).

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