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The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling.

Nat Commun · 2026 · PMC12976309 · PMID 41634047

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a clear trendno p-value reported
There is a clear trend for novobiocin to reduce CarD binding.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.