Plasma levels of thrombin-cleaved osteopontin as a surrogate biomarker of subsequent chronic shunt-dependent hydrocephalus development following aneurysmal subarachnoid hemorrhage.

Neurotherapeutics · 2026 · PMC12976512 · PMID 41708436

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

Plasma OPN N-half levels in patients with SDHC development showed a trend toward higher values at days 7–9 ( p = 0.058) and were significantly higher at days 10–12 ( p < 0.001) compared to patients without SDHC.

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