Tissue nonspecific and intestinal alkaline phosphatase crosstalk: a missing link in hypophosphatasia pathophysiology?

J Transl Med · 2026 · PMC12977700 · PMID 41656268

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highly significantno p-value reported

A highly significant association was observed, indicating that a 10-fold increase in IAP levels was associated with an approximate 8.3-fold increase in fecal ALP activity.

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did not reach statistical significanceno p-value reported

Although the relationship between serum TNSALP activity and fecal calprotectin did not reach statistical significance (probably due to the limited sample size of 30), the trend became significant when total serum ALP was analyzed.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.