ALDH1L1 reverses CD8<sup>+</sup> T cell exhaustion in the oral squamous cell carcinoma microenvironment by reprogramming L-glutamate metabolism.

While the suppression of IFN-γ secretion by the conditioned medium from CAL 27 KD cells did not reach statistical significance, a significant inhibitory effect was observed when using medium from SCC-25 KD cells (Fig. 2 G-H).

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