II - Evaluation of Autonomic Control of Heart Rate in Various Clinical Conditions.

8 As already pointed out above, the autonomic dysfunction in CD patients can be detected before the development of ventricular dysfunction and in all phases of the disease, even in those individuals with the indeterminate and isolated digestive forms 7 , 15 , 16 However, in some of our studies, there was a clear trend of patients showing parasympathetic cardiovascular dysfunction to have the typical CD digestive organ involvement, i.e., megaesophagus and or megacolon, whose pathophysiology is considered to be mostly due to visceral parasympathetic intramural denervation. 17 - 21 Although the neurogenic theory had been proposed as the fundamental pathogenetic mechanism for Chagas’ cardiomyopathy, 22 the pathogenesis of Chagas cardiomyopathy is definitely more complex, and the neurogenic theory for Chagas cardiomyopathy met several unsolvable conceptual obstacles.

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