did not reach statistical significanceP -value = .13
This analysis of the association of the RANO-TREAT composite score, with equal weighting of each item (ie, unweighted), with MRI outcome did not reach statistical significance with either progression or stability on MRI (OR: 1.009; 95% CI: 0.998–1.02; P -value = .13 in the primary brain tumor cohort and OR: 1.007; 95% CI: 0.996–1.02; P -value = .21 in the primary brain tumor with IDH mutation cohort) ( Figure 1A , Supplementary Figures 1 , 2 , 4 and Supplementary Table 3 ).