Metabolic dysfunction-associated fatty liver disease and risk of knee osteoarthritis: A prospective cohort study.

Clin Exp Med · 2026 · PMC12979261 · PMID 41784857

Europe PMC DOI

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did not reach statistical significanceno p-value reported

Among subtypes, MAFLD-overweight/obesity showed a significant association with KOA (HR 1.19, 95% CI 1.14–1.25), while MAFLD-diabetes (HR 1.05, 95% CI 0.96–1.16) and MAFLD-lean (HR 1.23, 95% CI 0.93–1.62) did not reach statistical significance.

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of borderline significanceno p-value reported

However, when accounting for death as a competing risk, an association of borderline significance emerged, implying that the competing risk of mortality in this older, higher-risk population may have masked the association with incident KOA.

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