Immunotherapy in hepatocellular carcinoma: translating mechanistic insights into clinical advances.

Clin Exp Med · 2026 · PMC12979367 · PMID 41784912

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did not reach statistical significanceno p-value reported

Although some of these studies did not reach statistical significance for OS, improvements in PFS and objective tumor responses suggest meaningful clinical benefit.

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narrowly missed statistical significanceno p-value reported

Yet, the larger phase III KEYNOTE-240 trial narrowly missed statistical significance for overall and progression-free survival, even though numerical improvements were observed [ 84 ].

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