Gentiopicroside alleviates type 2 diabetes mellitus by attenuating oxidative stress and reshaping gut microbiota in high-fat diet and streptozotocin-induced mice.

Front Nutr · 2026 · PMC12981063 · PMID 41835376

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High-throughput 16S rRNA sequencing further revealed that GPS significantly increased the Chao1 index and Observed_otus index, showed a trend of improving indices such as Shannon, Simpson, Pielou-e, Goods-coverage, and improved β -diversity in fecal samples from T2DM mice.

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