Sex-based heterogeneity in response to first-line immunotherapy plus chemotherapy in advanced esophageal squamous-cell carcinoma: a meta-analysis.

Front Immunol · 2026 · PMC12982060 · PMID 41836421

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In support of the findings from the previous meta-analyses, the stratification analysis of ESCORT-1 st trial included in the present study showed a trend toward more survival benefit from immunotherapy plus chemotherapy in advanced ESCC patients with baseline BMI ≥ 20 kg/m2 than those with baseline BMI < 20 kg/m2 (HR for OS: 0.65 vs. 0.82; HR for PFS: 0.52 vs. 0.59) ( 24 ).

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