Activation of M1mAChR's improves spatial learning and memory deficits in rats exposed to chronic intermittent hypoxia.

Interestingly, administration of AG490, VU0364572, or the combination produced nominal increases in hippocampal t-STAT3 and p-STAT3, but these changes did not reach statistical significance relative to CIH controls, suggesting that M1mAChR stimulation may be insufficient to fully restore STAT3 signaling under CIH.

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