Human type-1 innate lymphoid cells control leukemia stem cell differentiation and limit acute myeloid leukemia development.

Following analysis of ILC1s in the peripheral blood (PB) of healthy donors (HDs) and AML patients, we observed a highly significant increase in the percentage of ILC1s among total ILCs (CD127 + ) in AML patients relative to HDs (Fig. 1a and Supplementary Fig. 1a ).

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However, the injection of UCB CD34 + cell-derived CD161 − ILC1s showed a trend towards better prolongation of survival than the injection of UCB CD34 + cell-derived NK cells in our LSC model (Fig. 6j, k ).

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