Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy.

In addition, flow cytometric analysis of peripheral blood revealed that osalmid administration significantly increased the proportion of NKG2D CAR-T cells, reduced exhaustion markers including PD-1 in both CD4 + and CD8 + NKG2D CAR-T cells, while a reduction in Tim-3 was observed but did not reach statistical significance, and markedly increased the proportion of stem-like T cells (T SCM ) within the NKG2D CAR-T cell population compared with the group receiving NKG2D CAR-T alone ( figure 5J and K ).

also in 111,027 other papers