Reactive Stroma as a Transversal Prognostic Biomarker for Metastasis in Breast Cancer: Integration of Digital Histopathology and Transcriptomic Profiling.

Int J Mol Sci · 2026 · PMC12984561 · PMID 41828443

Europe PMC DOI

hedged sentence

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

did not reach statistical significancep = 0.073so close (0.05 < p ≤ 0.1)

Patients in the low total stroma group exhibited a significantly shorter MFS in the univariate analysis (HR = 4.11; 95% CI: 1.62–10.40; p < 0.001) ( Figure 2 D, Supplementary Table S1 ), and this trend persisted in the multivariate model, although it did not reach statistical significance (HR = 4.08; 95% CI: 0.88–18.94; p = 0.073) ( Supplementary Table S2 ).

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