Trifluridine/Tipiracil Plus Bevacizumab Versus Regorafenib in Elderly Patients with Refractory Metastatic Colorectal Cancer: A Real-World Comparative Study.

Cancers (Basel) · 2026 · PMC12984920 · PMID 41827721

Europe PMC DOI

hedged sentences

0.0280

closest p · 0.6× alpha

0.1020

boldest claim

The sentences

a numerical trendp = 0.028actually significant

Notably, while the univariate analysis for TTF showed a numerical trend, the expanded multivariate Cox regression identified the combination regimen as a significant independent predictor of favorable TTF (HR 0.44, p = 0.028), representing a 56% reduction in the risk of treatment failure after adjusting for key confounders, including treatment era and prior biologic use.

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did not reach statistical significancep = 0.102not close (p > 0.1)

3.4 months), although this trend did not reach statistical significance (log-rank p = 0.102, Figure 3 B). 3.3.

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