Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer's Disease.

Cells · 2026 · PMC12984946 · PMID 41827885

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did not reach statistical significanceno p-value reported

Although E2 induced a 20% increase in neurite length, it did not reach statistical significance and showed no effect on the other parameters ( Figure 4 B–D).

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highly significantno p-value reported

Crucially, the SLC25A23 promoter also harbors a highly significant ERRα/ERRβ motif, which NDUFA1 lacks.

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failed to reach significanceno p-value reported

In contrast, E2 failed to reach significance in Control cells and showed no effect in the P301L model.

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