Dictamnine Inhibits WNT Pathway and EMT Progression in Prostate Cancer and Remodels the Tumor Microenvironment.

And the enrichment of the “Wnt signaling pathway” itself did not reach statistical significance in either GO (GO:0016055, padj = 0.099) or KEGG (hsa04310, padj = 0.315) analyses, we noted that among the five candidate targets identified from the intersection analysis, DKK1—a gene with significant upregulation (|log 2 FC| > 1, padj < 0.05)—is a well-established secreted antagonist of the canonical Wnt/β-catenin pathway [ 30 , 31 ].

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