nominally significantp -value ≥ 0.05
Whenever applicable, a gene should show nominal significance (unadjusted p -value ≤ 0.05) and a concordant directionality for the effect estimate in sensitivity analyses, including the weighted median, MR-Egger, and MR-PRESSO, while the MR-Egger intercept should not be nominally significant ( p -value ≥ 0.05).