Fasting Enhances Cardiomyocyte Hypoxia Tolerance by Regulating Ca<sup>2+</sup> Transport at Mitochondria-Endoplasmic Reticulum Contact Sites.

A decreasing trend was also observed in the H + Con + 2-APB group relative to H + Con, though this did not reach statistical significance ( Figure 11 F).

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After acute hypoxia exposure, the myocardial apoptosis rate in the H + Con group reached 8.39 ± 0.10% ( p < 0.01), showing a highly significant increase, whereas the myocardial apoptosis rate in the H + CIF group increased to 1.17 ± 0.15% and was significantly lower than that in the H + Con group ( p < 0.01, Figure 2 B).

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The results showed that the left ventricular ejection fraction (LVEF) and left ventricular shortening fraction (LVSF) of rats significantly decreased after acute hypoxia ( p < 0.01), and the heart rate showed an increasing trend.

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The ROS level in the H + CIF group showed no significant difference compared with the N + Con and H + Con groups, but a decreasing trend was observed relative to the Con + H group ( Figure 5 C,D).

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