Investigation of Heterogeneity of Lipid Nanoparticles for Nucleic Acid Drug Delivery via Sucrose Gradient Density Centrifugation.

Differences were considered statistically significant at p < 0.05, and highly significant at p < 0.01.

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As shown in Table 3 , the overall physicochemical properties of the prepared LNPs did not exhibit a clear trend across the tested flow rates.

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From an overall trend perspective, the majority of components in the PEG 0.5% formulation LNPs are distributed in the upper layer of the gradient column.

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Most particles exhibit diameters exceeding 200 nm, with a decreasing trend in zeta potential and poor stability.

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