Clonal Dynamics of FLT3-ITD from Diagnosis to Relapse: Ultra-Sensitive Patient-Specific Monitoring by ddPCR.

In the overall cohort (n = 12), the median time to relapse was 370 days in the early ddPCR group and 938 days in the non-early group Although the exploratory log-rank test did not reach statistical significance ( p = 0.099), these data suggest that the presence of microclones undetectable by current standard methods may be associated with a worse outcome, reinforcing the urgency of developing ultrasensitive methods.

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