Effectiveness and Safety of the Combination of Paracetamol 1000 mg and Ibuprofen 300 mg Versus Ibuprofen 600 mg in Monotherapy in Acute Low Back Pain: Results from a Phase IV Randomized Study.

J Clin Med · 2026 · PMC12985560 · PMID 41827438

Europe PMC DOI

hedged sentences

0.0539

closest p · 1.1× alpha

0.0539

boldest claim

The sentences

showed a trendp = 0.0539so close (0.05 < p ≤ 0.1)

Although no significant differences were observed, the analysis showed a trend towards a greater improvement in LBP for the paracetamol 1000 mg/ibuprofen 300 mg group ( p = 0.0539) at visit 1.

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a positive trendno p-value reported

Moreover, statistically significant differences were obtained in the CGI-I at visit 1 and a positive trend was found in favour of paracetamol 1000 mg/ibuprofen 300 mg in the PGIC at visit 1 and for sitting disabilities in the ODI at visit 2.

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