Pregnanolone Glutamate: A Dual-Fate Delivery System for Neuroactive Steroids in Perinatal Focal Cerebral Ischemia.

We note that while the core findings of this study—including the massive increases in pregnanolone, its conjugate, 17-hydroxypregnanolone, and 5β-pregnane-3α,20α-diol—withstand stringent FDR correction (q < 0.001; Table 2 ), a subset of nominally significant changes in minor downstream metabolites (e.g., epietiocholanolone conjugate, 5β-androstane-3α,17β-diol conjugate) should be interpreted as exploratory observations pending independent replication ( Table 2 , footnote).

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