Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis.

PI outcomes showed a small but significant benefit for grape seed extract at three months ( p < 0.05) ( Figure 21 A), whereas no significant heterogeneity was detected (I 2 = 0%) at six months ( Figure 21 B).

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BOP showed a trend toward reduction in the omega-3 group, although the confidence intervals crossed the null value, and heterogeneity emerged at three months ( p < 0.05) ( Figure 11 A,B).

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