<i>Latilactobacillus curvatus</i> IM01 Alleviates Allergic Airway Inflammation Through Microbial and Metabolic Crosstalk Along the Gut-Lung Axis.

Although Gata3 expression exhibited a decreasing trend, this difference was not statistically significant.

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Specifically, compared to the control group, OVA-challenged mice exhibited a trend toward decreased relative abundances of Lactobacillus and Odoribacter , whereas the abundances of Lachnospiraceae_NK4A136 and Alistipes showed an increasing trend.

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This microbial restructuring was closely associated with a modulated cecal metabolic profile, as untargeted metabolomics exhibited a clear trend toward the restoration of key systemically active immunoregulatory metabolites, including indolelactic acid (ILA) and choline, which have been previously linked to the alleviation of AAI symptoms.

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